??????????????????????????????в???H5??????????????
???????????????????????????????в???????????Ч??????????????????к???????????????????????????????????в???H5??????????????( H5 N1??Re-6??+ Re- 7??)??????????????????????????????????????????в???H5??????????????( H5 N1??Re-6??+ Re- 7??) ???????????ɡ???????????????????????Ч????
1 ????????
1.1 ???????
??????????????????????????????в???H5??????????????( H5 N1??Re-6??+ Re- 7??)??????硣
????????? ??????H5N1 Re-7???Re-6???????????壬???й?????????????????о??????????????????????????????????????????????????SPF???????????
1.2 ????Ч?????
?4????SPF??35?????????????????????????SPF????????????????飬???????飬???20?????????15?????????????????????????????????????H5?????????????磬?????????????0.5ml??21???????顢??????????????????壬????ù????????вο??????????????????в???Re-6???Re-7??????????2??H5????????HI???塣
1.3???鼦?
???4????δ??????????????????????????????????????????(A??)??????У?B????????????????15000???????????????????????????????????????H5?????????????硣??????????????????????????
1.4 ????????????? ?????????????????????????4??????????????????0.3 mL????8?????????????????0.5 mL????
1.5 HI????Ч??? ?????4????????????6????7????8????(??????)??9????10????12????14????17????20????23????26????????????150?????????????????????岢?????????????????????????( HI )???п?????
1.6????????????
??????ù?????????????????????( HI )???п????????????HI????ζ????????6log2????????
2 ???
2.1????Ч????????????1???????????????????Re-6??Re- 7??HI???弸??????ζ??GMT????6log2????????
??1 ????Ч?????????log2??
|
?? |
Re-6?? |
Re-7?? |
|
??????????? 201409 |
6.4 |
6.3 |
|
?????? |
0 |
0 |
2.2 ????????????????????????????????δ???????????????????????????????????Re-6??Re-7??HI????Ч????????????????????????2???????????????????????1???2??
??2 ??????H5N1????Re-6??Re-7??HI????Ч????????log2??
|
???? |
Re-6??log2?? |
?? |
Re-7??log2?? |
||
|
A???? |
B???? |
?? |
A???? |
B???? |
|
|
4 |
1.4??1.2 |
1.4??1.1 |
|
1.1??0.88 |
1.1??0.88 |
|
6 |
5.8??1.2 |
6??1.5 |
|
6.4??0.7 |
6.1??1.7 |
|
7 |
7.6??1.6 |
8??1.2 |
|
8.2??1.3 |
8.4??1.6 |
|
8 |
7.4??1.3 |
7.9??1.1 |
|
7.9??1.5 |
7.8??1.9 |
|
9 |
8.2??1.5 |
8??1.2 |
|
8.5??1.6 |
8.4??1.6 |
|
10 |
9.1??2.2 |
9??2.5 |
|
9.5??0.9 |
9??1.7 |
|
12 |
10.3??1.4 |
9.7??1.1 |
|
10.1??1.7 |
9.4??1.5 |
|
14 |
11.6??0.8 |
11??1.8 |
|
11.4??1.2 |
10.9??2.1 |
|
17 |
10.9??2.2 |
11.4??1.2 |
|
11.2??2.3 |
11.3??0.9 |
|
20 |
10.3??2.6 |
10??1.3 |
|
10??1.2 |
9.5??1.6 |
|
23 |
7.6??1.7 |
7??1.5 |
|
7.7??2.3 |
6.9??2.2 |
|
26 |
6??2.4 |
5.7??1.7 |
?? |
6.3??1.4 |
5.9??1.8 |
???1???2??????????????????????????????????????2???A???顢B????Re-6??Re-7????Ч???6log2??3??????????????????壬Re-6????6.9~8log2??Re-7????8~8.4log2???????????Ч???????????????8???????????????????Ч???????????????A??????Ч????????????6???14??????????????????????Re-6?????11.6log2??Re-7?????11.4log2??B????????????????????????????9????????塣???????????????Ч???????????????18???A??????B????Re-6??Re-7????Ч???????6log2???????????????16~18???
2.3 ????????????饗t ???飩A????B??????????????????(P<0.05)??A????B????????????P>0.05????
3 ????
???HI????Ч????????????4log2???ж???????????й??????HI????Ч???4log2??б???????????????????????????5log2?????????????????????????????????????????????????????翹?????????????????????????????????6log2????????????????????????
?????????У?????????????????????????????????????????????????????????????λ??????????????в???H5??????????????( H5 N1??Re-6??+ Re- 7??)???????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????16~18???????????ζ??????????5~6??????????????????????HI????Ч??????????????????????????м????????????????????????????????????????????????????????????H5?????????????????15~30???????????45~60??????ж????????????????????????????????????????????????????????????????????????????????HI??????????????????????????????????H9?????????????????
?????????й??????????????·277??
?????????23011002000697?? ??????????????????????